Upper Limb Strength, Function Worsen Over Time in DMD – Muscular Dystrophy News

Upper limb strength, function, and muscle fat fraction continuously worsen over time in Duchenne muscular dystrophy (DMD) patients with mutations amenable to exon 53 skipping, according to three-year data from a natural history study.

Notably, this progression of upper limb involvement was assessed reliably with strength, function, and muscle MRI measures in patients who could still walk (ambulatory) and those who had lost such ability (non-ambulatory), supporting their use as outcomes in DMD clinical trials.

In addition, a combination of low grip strength and high forearm muscle fat fraction was able to predict the loss of walking skills in ambulatory patients and the loss of the ability to drink from a glass of water independently in non-ambulatory patients in the next three years.

Read more at: https://musculardystrophynews.com/?p=72190

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