Why Do Proteins Misfold? The Answer Could Point to Parkinson’s Disease Therapies – Technology Networks

Photomicrographs of regions of substantia nigra in this Parkinson’s patient show Lewy bodies and Lewy neurites in various magnifications. Lewy bodies are protein clumps consisting of alpha-synuclein and other associated proteins. Credit: Suraj Rajan / CC BY-SA (https://creativecommons.org/licenses/by-sa/3.0)

 

A group of researchers have identified identified a link between the structure of the disease-linked protein alpha-synuclein and its potential to aggregate and misfold.

Alpha-synuclein aggregates are the hallmark of neurodegenerative disorders, such as Parkinson’s disease. Their findings, published today in Nature Communications, identify potential new therapeutic targets in the treatment of Parkinson’s disease.

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