Two Landmark Studies Advance Focused Ultrasound Treatment for Parkinson’s Disease – BioSpace

José Obeso, MD, PhD, (left) of of the Centro Integral de Neurociencias (HM CINAC) in Madrid and Nir Lipsman, MD, PhD, (right) of Sunnybrook Health Sciences Centre in Toronto. Each doctor is leading a clinical trial using focused ultrasound to target the striatum in patients with Parkinson’s disease.

A team of researchers in Madrid, Spain, and another team in Toronto, Canada, are the first in the world to use focused ultrasound technology to target a new area of the brain in patients with Parkinson’s disease and potentially curb, or even reverse, its progression.

Both ongoing clinical trials focus on the striatum, a hub of neurons deep in the brain that is one of the principal components of the basal ganglia – an area that plays a central role in facilitating voluntary movement. The severity of movement-related symptoms of Parkinson’s is associated with the neurodegeneration of dopaminergic nigrostriatal projection.

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