The Placebo Effect Is Real in Depression Studies – Psychiatry Advisor

The researchers found that although the combined placebo effect size for all interventions was large, the placebo effect sizes for each treatment modality did not significantly differ. Credit: Getty Images

Clinical trials for treatment-resistant depression have been found to show a large placebo effect in a recent meta-analysis published in JAMA Psychiatry. The findings serve as a placebo effect size benchmark that researchers can use to interpret findings from future studies.

As people with treatment-resistant depression often experience lower rates of response and remission, it is important to quantify the magnitude of the placebo effect in clinical trials.

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