Exosomes — tiny vesicles secreted by cells — collected from bone marrow stem cells and injected into a mouse model of multiple sclerosis (MS) helped to treat the disease, a study reports.
Specifically, this treatment eased myelin loss and neuroinflammation in the mice, and improved motor function, the researchers said. These results suggest that stem cell therapies for autoimmune and neurodegenerative diseases — perhaps ones not using cells directly — may one day be possible.
“This novel treatment will be tested on humans in early 2020, initially on people with type 1 diabetes,” Milad Riazifar, the study’s co-lead author and a doctoral student in pharmacological sciences assisting in the design of a City of Hope trial using this approach, said in a press release.
“If successful, it could pave the way for treating other autoimmune diseases, including multiple sclerosis,” he said.