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  • Scientists create novel genetic model of Down syndrome in rats – Johns Hopkins Medicine

Scientists create novel genetic model of Down syndrome in rats – Johns Hopkins Medicine

Wednesday, 16 March, 2022

Scientists create novel genetic model of Down syndrome in rats – Johns Hopkins Medicine

The facial differences in rats with an extra 21st chromosome mapped on the skull by a computer program. Credit: Roger Reeves and Johns Hopkins Medicine

 
In pursuit of better ways to test new therapies and further explore the impacts of the unique genetics associated with Down syndrome, researchers at Johns Hopkins Medicine and Tottori University in Japan have genetically engineered and characterized what is believed to be the first rat model of Down syndrome.
A report of their research appeared Jan. 24 in The American Journal of Human Genetics.
Scientists have long sought ways to improve medical care for people with Down syndrome, especially those suffering the physical and mental challenges that are hallmarks of the condition. These include a higher risk of heart defects, gastrointestinal problems and difficulties with learning and memory.
Read more at: https://www.hopkinsmedicine.org/news/newsroom/news-releases/scientists-create-novel-genetic-model-of-down-syndrome-in-rats

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