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Researchers on the path to finding a cure for spina bifida have identified specific elements in stem cell secretions as key to protecting neurons and ultimately reducing the lower-limb paralysis associated with the birth defect.

Those elements are exosomes — vesicles that transfer molecules from cell to cell — and a small carbohydrate-binding protein known as galectin 1.

The team will use the results to optimize the neuroprotective qualities of a stem cell treatment they developed to improve the mobility issues associated with spina bifida.

Published in The FASEB Journal,, the study was led by Aijun Wang, co-director of the UC Davis Health Surgical Bioengineering Laboratory.

Altering the outcomes of spina bifida

UC Davis Health fetal surgeon and study co-author Diana Farmer first showed that prenatal surgery reduces neurological defects in children with spina bifida, which occurs when the spinal cord does not properly close before birth. Children with the condition experience a range of lifelong cognitive, urological, musculoskeletal and motor disabilities.

Farmer and Wang, her chief collaborator, later showed that prenatal surgery combined with human placenta-derived mesenchymal stromal cells (PMSCs) improved hind limb control in lab animals and dogs with spina bifida.

“We wanted to know the specific mechanisms of action of the PMSC treatment that protect neurons,” Wang said. "Our new results provide evidence that stem cell secretions containing exosomes that express galectin 1 are an important part of the therapeutic benefits and give us a path for optimizing the neuroprotective qualities of the treatment."

Read more at: https://health.ucdavis.edu/publish/news/newsroom/13630