In a recent study published in Science Advances, a research team led by Profs. Dai Jianwu and Zhao Yannan at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences demonstrated a strategy for covalent conjugation between biomaterials and cells to construct spinal cord-like tissue with drug-guiding function for spinal cord injury (SCI) repair.
SCI repair is one of the world’s most challenging medical problems. Engineered spinal cord-like implants based on stem cells and biomaterials provide a new method for improving therapeutic outcomes for SCI. The adhesion of stem cells to scaffolds can be regulated by the stiffness, surface topological structure and porosity of the scaffold, as well as by the modification of integrin ligand or adhesion molecules based on noncovalent interactions.
Read more at: https://phys.org/news/2023-02-spinal-cord-like-tissue-drug-guiding-function.html