In a new paper published in Scientific Reports, researchers at Children’s Hospital of Philadelphia (CHOP) have identified and characterized genetic pathways shared by epilepsy and autism spectrum disorder (ASD), two heterogenous brain disorders. Further exploration of the findings could lead to better, more personalized treatments for both conditions.
Epilepsy and ASD are two broad categories of brain disorders that overlap with surprising frequency. For example, some 30% of patients with ASD also have epilepsy, whereas the seizure disorder occurs in only 2-3% of the general population. While the reason for this overlap has not been identified, one hypothesis is that both conditions involve the disruption of shared neurodevelopmental pathways implicated by the relatively high number of genes associated with both disorders.
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