Novel hydrogel promotes neural regeneration after spinal cord injury – Medical Xpress

Schematic diagram of the dual-functional immunoregulatory hydrogel for regulating the inflammatory microenvironment after spinal cord injury. Credit: IGDB

Researchers led by Prof. Dai Jianwu from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences developed a multifunctional scaffold to effectively regulate the immune microenvironment after spinal cord injury and reduce secondary injury effects, according to a recent study published in Biomaterials.

By modifying a photocrosslinking gelatin hydrogel with a cationic polymer, polyamidoamine, and an anti-inflammatory cytokine, interleukin-10 (IL-10), the scaffold could enhance tissue remodeling and promote axonal regeneration.

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