New trial platform could accelerate finding a cure for Parkinson’s disease – EurekAlert

Despite 30 years of research, not a single therapy has been found to successfully delay or stop the progression of Parkinson’s disease (PD). In the Journal of Parkinson’s Disease scientists report on the possibility of using a multi-arm, multi-stage (MAMS) trial platform to evaluate several potential therapies at once, using lessons learned from other diseases.
CREDIT: Cure Parkinson’s Trust

 

Despite 30 years of research, not a single therapy has been found to successfully delay or stop the progression of Parkinson’s disease (PD). In the Journal of Parkinson’s Disease scientists report on the possibility of using a multi-arm, multi-stage (MAMS) trial platform to evaluate several potential therapies at once, using lessons learned from other diseases.

Many potential disease-modifying therapies have been identified as suitable for clinical evaluation in PD. Each potential cure for PD has to go through three clinical trial phases to test its safety, whether it shows signs of improving PD, and whether there is any meaningful benefit to people with PD. Running a clinical trial is a huge logistical, costly, and time-consuming undertaking. For a single new therapy this process can take the best part of a decade. Currently, phase II and phase III clinical trials in PD are set up in isolation from each other, a process that is lengthy, costly, and inefficient.

Click here to read full article https://eurekalert.org/pub_releases/2020-05/ip-ntp050620.php

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