In a recent study published in the journal PNAS, researchers investigate the pronociceptive role of neutrophils in fibromyalgia using a murine model of chronic pain through hyperalgesic priming.
Background
Fibromyalgia is a debilitating condition with chronic pain known to originate from central nervous system (CNS) dysfunction; however, recent studies have reported a peripheral nervous system (PNS)-associated etiology of this condition. Immune dysregulation has been observed in fibromyalgia, including an increase in the number of neutrophils with enhanced microbicidal and chemotactic properties.
