Negative memory storage affects depression symptoms – Medical Xpress

Fluorescent-tagged cells in the hippocampus (A), including engram cells (D). Credit: Zhang et al., JNeurosci 2019

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to research in mice published in JNeurosci. Inhibiting these manifestations could be a future treatment route.

Groups of neurons that are activated after an experience are thought to be the physical representation of memory. These so-called engrams in the hippocampus could be involved in depression, which is characterized by impaired recall of positive memories and increased recall of negative memories.

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