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The parents of a 17-year-old boy with severe epilepsy will join 15 other families in Westminster to call for more access to medical cannabis.
It was legalised in November but Rachel Rankmore said her son Bailey has been denied the more potent cannabis oil.
He has been taking non-psychoactive CBD oil for three years but she said doctors have refused to prescribe him the stronger, full extract oil.
Ms Rankmore said the refusal had made the family anxious and unwell.
The 16 families will hand in a petition at Downing Street calling for medical cannabis to become more widely available.
It coincides with a meeting of the health and social care select committee about medical cannabis.
Home Secretary Sajid Javid said specialist doctors could prescribe cannabis-based medicines legally for patients with an "exceptional clinical need" from last autumn.
Ms Rankmore, from Cardiff, told BBC Radio Wales: "There was a day of elation when the law changed - it sort of opened up our hopes and dreams because it meant we could give Bailey his quality of life back.
"But now we are getting a complete block."
Read more at: https://www.bbc.com/news/uk-wales-47623046