Maximum body mass index (BMI) before the onset of type 2 diabetes (MBBO) is independently associated with complications of the disease but BMI on admission is not, according to a study in BMJ Open Diabetes Research & Care.
Researchers retrospectively reviewed data from 1304 consecutive patients who were admitted to a hospital in Japan for treatment of poor glycemic control from August 2010 to June 2017. Investigators sought to evaluate whether MBBO or BMI could predict progressive diabetic retinopathy or diabetic nephropathy in patients with type 2 diabetes (T2D).
Univariate and multivariate analyses were performed by logistic regression models to predict outcomes of advanced retinopathy or nephropathy. In the multivariate analyses, to assess the effect of BMI, MBBO, and age at MBBO on prediction, a model was developed using a stepwise method with backward selection for all variables that excluded them. Cross-validation was used to determine whether adding these factors to the model would improve prediction accuracy.