Altered connections between the cerebellum, a brain region important for coordinating voluntary movements, and the cerebral cortex, involved in higher-level processes, are associated with greater severity of Friedreich’s ataxia (FA), an MRI study showed.
Unusual changes in connectivity also were seen to correlate with damage to the brain’s white matter.
Together, these results contribute to the view that FA is a “whole-brain” disease and support links between imaging markers of brainwide abnormalities, the researchers noted.
