Exercise May Slow Cognitive Decline in At-Risk Patients With Parkinson Disease – AJMC.com

Exercise may reduce vulnerability to cognitive decline among at-risk patients with Parkinson disease who have the gene variant APOE ε4.

Exercise may reduce vulnerability to cognitive decline among patients with Parkinson disease (PD) at greater risk due to the gene variant apolipoprotein E ε4 (APOE ε4), according to study findings published today in Neurology.

As a major genetic risk factor for Alzheimer disease (AD), the APOE ε4 allele has been shown to affect cognition in patients with AD mainly through amyloid-related pathways. Although, the researchers noted that recent evidence has indicated that the allele may also exacerbate alpha synuclein pathology in the brain, which would then lead to accelerated neurodegeneration in patients with PD.

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