Do high dose vitamin D supplements affect MS symptoms? – MS Trust

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The study in brief

People with MS are often advised to take high doses of vitamin D, but there’s been very little research to assess what effect this might have. Two recent clinical trials (CHOLINE and SOLAR) investigated the effect of vitamin D supplements in people with relapsing remitting MS already taking a disease modifying drug.

CHOLINE: 129 participants already taking Rebif (beta interferon 1a) and with low blood levels of vitamin D were recruited at 27 MS clinics in France. They were randomly assigned to take either 100,000 IU vitamin D3 (equivalent to about 7,000 IU/day) or placebo, once a fortnight for just under two years. The main measure of the study was a change in the number of relapses.

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