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Difference in brain connectivity may explain autism spectrum disorder – University of Alabama at Birmingham

Researchers at the University of Alabama at Birmingham have identified a possible mechanism of human cognition that underlies autism spectrum disorders, or ASD.

Diagnosis for ASD is still behaviorally based. Psychologists and medical professionals with clinical expertise use the Autism Diagnostic Observation Schedule and the Autism Diagnostic Interview to diagnose autism — these two tests are considered the gold standard.

However, getting a diagnosis can be a longer process due to several factors, including lack of resources and trained clinicians. This delays autism diagnosis, on average, until age 5 or 6.

“Within ASD, two important research questions are: How can we minimize the delay in diagnosis, and what kind of intervention can we give the child?” said Rajesh Kana, Ph.D., associate professor of psychology in the UAB College of Arts and Sciences. “Our findings primarily respond to the first question; but if study results can be replicated many times for external validity, they can also be used in finding answers for the latter question.”

Utilizing functional magnetic resonance imaging, or fMRI, postdoctoral fellow Omar Maximo, Ph.D., and Kana examined 306 people from ages 8 to 39, with 138 individuals in the ASD group and 168 individuals in the typically developing group. They looked at functional connectivity, which refers to the synchronization of activity across different brain regions, on two types of networks, unimodal and supramodal, in areas of the brain underneath the cerebral cortex. The subcortical areas contain structures that receive inputs from and to the cortex and sensory organs, and play a large role in cognitive and social functions.

Read more at: https://www.uab.edu/news/research/item/10129-difference-in-brain-connectivity-may-explain-autism-spectrum-disorder

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