Chinese neuroscientists have identified a bone marrow (BM) response to acute brain injury, in which the fate and function of BM hematopoietic cells are shaped by brain injury, suggesting that the brain can mobilize a population of protective monocytes and direct them to the injury site.
This mechanism’s recognition could pave the way to developing protective brain therapies by harnessing beneficial BM hematopoiesis for acute neurological insults such as intracerebral hemorrhage (ICH), the authors reported in the April 14, 2021, edition of Science Translational Medicine.
The BM offers a unique niche for neuroimmune interactions in health and disease, as the intersection of the CNS, peripheral immune system, and the site of leukocyte production.
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