Pregnant women with bipolar disorder (BD) receiving psychotropic medication did not experience improvement in either functional impairment or symptom burden, according to a study published in Bipolar Disorders Journal.1
Dr Kara E. Driscoll from the University of Pittsburgh in Pennsylvania, and colleagues conducted a naturalistic study of 152 pregnant women with BD at or prior to 20 weeks' gestation. Maternal assessments were completed at 20, 30, and 36 weeks' gestation, and 2, 12, 26, and 52 weeks postpartum using the Structured Interview Guide for the Hamilton Depression Rating Scale-Atypical Depression Supplement (SIGH-ADS), which contains the 17-item Hamilton Rating Scale for Depression (HAM-D-17), and Mania Rating Scale (MRS).
Outcome measurements were compared in 3 groups of women: women who received no psychotropic medication (42.1% of participants), women who stopped taking psychotropic medication after their first trimester (15.1%), and women who took psychotropic medication throughout their pregnancy (42.8%).
At all 3 assessments, mean SIGH-ADS scores (16.5-19.6) indicated mild to moderate severity while mean scores for HAM-D-17 (10.4-12.8) were similar in all 3 groups of women with BD.