Alzheimer’s disease ‘can develop without symptoms in those with Down’s syndrome’ – The Irish News

Researchers say the findings can now inform the development of future clinical trials.

People with Down’s syndrome can develop brain changes associated with Alzheimer’s disease by their forties, with no clinical symptoms to help detect them, new research suggests.

The study found that cognitive and biochemical changes in Alzheimer’s disease start more than 20 years before clinical symptoms appear in people with Down’s syndrome.

In adults with the syndrome, the earliest changes detected by researchers were at the age of 30.

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